Frank Welker
Scooby-Doo / Fred Jones (voice)
Grey DeLisle
Daphne Blake (voice)
Mindy Cohn
Velma Dinkley (voice)
Matthew Lillard
Shaggy Rogers (voice)
Patrick Warburton
Sheriff Bronson Stone (voice)
Gary Cole
Mayor Fred Jones Sr. / Paramedic #2 (voice)
Lewis Black
Mr. E (voice)
Vivica A. Fox
Cassidy Williams (voice)
Udo Kier
Professor Pericles (voice)
Kate Higgins
Principal Quinlan (voice)
Frances Conroy
Angie Dinkley (voice)
Tia Carrere
Amy (voice)
Tim Matheson
Brad Chiles (voice)Mitch Watson
Dylan (voice)
Kath Soucie
Nan Blake / Female Tourist (voice)
Linda Cardellini
Marcie 'Hot Dog Water' Fleach / Airport PA (voice)
John O'Hurley
Skipper Shelton (voice)
Dee Bradley Baker
Officer Johnson (voice)
Maurice LaMarche
Vincent Van Ghoul (voice)
Tony Cervone
Gary (voice)
Casey Kasem
Colton Rogers (voice)
Fred Tatasciore
The Phantom (voice)
James Arnold Taylor
Randy (voice)
Troy Baker
Dreamweaver (voice)
Amy Acker
Nova (voice)
Jeff Bennett
Dougal McGuiness (voice)
Kimberly Brooks
Luna (voice)
Jennifer Hale
Daisy Blake (voice)
Carlos Alazraqui
Piranha-Goat / Deputy Bucky / Nitro Wleinski (voice)
Tom Kenny
Funky Phantom (voice)
David Kaye
Dad (voice)
Richard McGonagle
Ed Machine (voice)
Matt Lanter
Baylor Hotner (voice)
Clancy Brown
Hebediah Grim (voice)
Christian Lanz
Fernando El Aguirre (voice)
Mindy Sterling
Dean Fenk (voice)
Beth Tapper
Brenda (voice)
James Patrick Stuart
Dr. Rick Spartan
Kevin Michael Richardson
Hulking Red (voice)
Kevin Dunn
Dale Dinkley / Workman #1 (voice)
